Odyssey Sims added 20 points for Baylor, including three 3-pointers in the first 4 minutes after halftime.
Anna Prins had 20 points and Nikki Moody 12 for the Cyclones (23-8) in their first Big 12 title game since 2007.
Iowa State got off to a good start with Prins making a 3-pointer on its opening attempt before another long-range shot by Hallie Christofferson for a 6-5 lead. But the Cyclones then went more than 8 minutes without scoring, a span in which they missed six shots and had eight turnovers while Baylor scored 19 points in a row for a double-digit lead that only got bigger.
Baylor had the lead for good at 7-6 on Griner’s putback after she grabbed the rebound of her only missed shot out of 12 attempts in the first half.
The Lady Bears were up 41-13 at the break, holding Iowa State to the fewest points ever in a single half of a Big 12 tournament championship game.
Baylor’s fifth Big 12 tournament title — all coming in a stretch that began in 2005, the year of its first national title — broke a tie with Oklahoma for the most in the league.
The Lady Bears will surely be the No. 1 overall seed in the NCAA tournament and will play their first games in two weeks on the Waco campus, where they have won a nation-best 55 games in a row.
They have won 30 straight overall since losing against Stanford at a tournament in Hawaii a week into the season.
“It’s always good to send a statement going into the NCAA tournament,” Sims said. “We’re just going out there having fun, one game at a time.”
Griner finished 14 of 17 shooting and had as many field goals as Iowa State’s entire team when she came out of the game for good with 4:12 left.
When Griner got near the Baylor bench, she shared a long hug with Mulkey while getting a large ovation from an adoring crowd with the game being played only about 100 miles from the Baylor campus.