With talent-packed Brazil and robust Serbia also in Group G, taking three points in the early afternoon heat on Thursday shapes as a key step for each team to advance.
The task is harder for Cameroon based on recent World Cup form after being swept aside in three straight losses at each of its past two appearances, in 2014 and 2010.
That 2014 tournament started badly when the players first refused to board their flight to Brazil in a dispute with the soccer federation over pay and bonuses.
“Things have changed. We are pleased that all the mistakes in the past have not been repeated," Cameroon coach Rigobert Song, the nation's most capped player, said Wednesday.
In that recent period the Indomitable Lions have scored fewer goals collectively as a team on soccer’s biggest stage than a single Swiss player, Xherdan Shaqiri.
The score is 4-3 in Shaqiri’s favor since 2010 when he made his World Cup debut as a teenager. Now 31 and playing in MLS with Chicago Fire, Shaqiri returns again as playmaker equaling a Swiss record at his fourth edition of the tournament.
Goals will more likely come this time from Cameroon-born Breel Embolo, the in-form Monaco forward, who left the country 20 years ago.
“Since the draw (in April), it is like the 10,000th time I get this question," the 25-year-old Embolo said this week about facing Cameroon. “It’s a special game for me and my family. But it’s not the most important, the most important is that it’s a World Cup game.”
At age 33, Cameroon’s star forward Eric Maxim Choupo-Moting arrives at his third edition in prolific form at Bayern Munich and looking for his first career World Cup goal.
Choupo-Moting’s 11 goals in all competitions this season helped plug the gap left by Robert Lewandowski’s departure and lifted Bayern back atop the Bundesliga at the enforced mid-season break.
Both Cameroon and Switzerland come to Qatar with solid results at their continental championships in the past 18 months though each now with different coaches.
At the European Championship last year, the Swiss broke a streak of being stopped at the round of 16 in major tournaments by eliminating France on penalties after a 3-3 thriller.
After losing another shootout in the quarterfinals to Spain, coach Vladimir Petkovic parlayed his rising reputation after seven years into joining Bordeaux. He was fired within months.
Murat Yakin, a 49-times capped central defender immediately impressed by steering the team to finish top of a World Cup qualifying group ahead of European champion Italy.
“I am convinced we will perform the best World Cup ever,” Yakin said Wednesday in translated comments. Switzerland reached the quarterfinals three times, though not since 1954 as host nation.
Cameroon started the year reaching the semifinals at the African Cup of Nations it hosted — losing on penalties to Egypt — then fired Portuguese coach Toni Conceição.
Samuel Eto’o, Cameroon's greatest player and now its federation president, turned to his long-time former teammate Song, who had a patchy record of results coaching within the national teams’ setup.
Song was the captain and Eto’o scored the only goal when Cameroon last won a World Cup game, 20 years ago in Japan against Saudi Arabia.
It is overdue for Africa’s first World Cup quarterfinalist, in 1990, to rediscover winning form.